Mary Lou Guerinot
Professor of Biological SciencesRonald and Deborah Harris Professorship in the Sciences
I study the molecular mechanisms of metal ion uptake and its regulation in prokaryotic and eukaryotic cells using a combined genetic, molecular, and biochemical approach. My goal is to understand the functional connections between genes, proteins, metabolites, and mineral ions. I’m also looking at the reduction of iron by a family of membrane-bound Fe(III) reductases and metal metabolism in the symbiosis between Bradyrhizobium japonicum and soybeans.
Baxter, I, B Muthukumar, H C Park, P Buchner, B Lahner, J Danku, K Zhao, J Lee, M J Hawkesford, M L Guerinot, and D E Salt, “Variation in Molybdenum Content Across Broadly Distributed Populations of Arabidopsis thaliana Is Controlled by a Mitochondrial Molybdenum Transporter (MOT1),” PLoS Genetics , 4:2 (2008) e1000004.
Jeong, J, C Cohu, L Kerkeb, M Pilon, E L Connolly, and M L Guerinot, “Chloroplast Fe(III) Chelate Reductase Activity is Essential for Seedling Viability Under Iron Limiting Conditions,” Proc. Natl. Acad. Sci. U.S.A., 105:30 (2008) 10619-10624.
Baxter, I, O Vitek, B Lahner, B Muthukumar, M Borghi, J Morrissey, M L Guerinot, and D E Salt, “The Leaf Ionome as a Multivariable System to Detect a Plant’s Physiological Status,” Proc. Natl. Acad. Sci. U.S.A. 105:33 (2008) 12081-12086.
Kim, S A, T Punshon, A Lanzirotti, L Li, J M Alonso, J R Ecker, J Kaplan, and M L Guerinot, “Localization of Iron in Arabidopsis Seed Requires the Vacuolar Membrane Transporter VIT1,” Science , 314 (EPub Nov 2006) 1295-1298.
Eide, D J, S Clark, T M Nair, et al., “Characterization of the Yeast Ionome: A Genome-wide Analysis of Nutrient Mineral and Trace Element Homeostasis,” Genome Biology , 6:9 (2005) R77.
Colangelo, E P, and M L Guerinot, “The Essential Basic Helix-loop-helix Protein FIT1 is Required for the Iron Deficiency Response,” Plant Cell , 16 (2004) 3400-3412.