David J. Bucci
Chair, Department of Psychological and Brain SciencesRalph and Richard Lazarus Professor of Psychological and Brain Sciences
My research is concerned with the brain mechanisms underlying learning, memory, and attention. Current studies utilize modern behavioral, chemogenetic, neuroanatomical, and biochemical techniques in rodent models to examine the role of cortical structures and subcortical neurochemical systems in these processes. The ultimate goal of this research is to further our understanding of basic mechanisms of information processing in the brain and ultimately relate these findings to the biological basis of cognitive dysfunction in humans.
Meyer, H.C. and Bucci, D.J. (in press) Imbalanced activity in the orbitofrontal cortex and nucleus accumbens impairs behavioral inhibition. Current Biology.
Chang, S.E., Todd, T.P., Bucci, D.J., and Smith, K.S. (2015) Chemogenetic manipulation of ventral pallidal neurons impairs acquisition of sign- tracking in rats. European Journal of Neuroscience, 42, 3105-3116.
Robinson, S. Todd, T.P., Pasternak, A.R., Luikart, B.W., Skelton, P.D., Roth, B.L., Urban, D.J., and Bucci, D.J. (2014) Chemogenetic silencing of retrosplenial cortex neurons disrupts sensory preconditioning. Journal of Neuroscience, 34, 10982–10988.
Meyer, H.C. and Bucci, D.J. (2014) The ontogeny of learned inhibition. Learning & Memory, 21, 143-152.
Robinson, A.M. and Bucci, D.J. (2014) Physical exercise during pregnancy enhances object recognition memory in adult offspring. Neuroscience, 256, 53-60.
Robinson, S., Poorman, C.A., Marder, T.J., and Bucci, D.J. (2012) Identification of functional circuitry between retrosplenial and postrhinal cortices during fear conditioning. Journal of Neuroscience, 32, 12076-12086.
Hopkins, M.E., Davis, F.C., VanTieghem, M., Whalen, P.J., and Bucci, D.J. (2012) Differential effects of acute and regular physical exercise on cognition and affect. Neuroscience, 215, 59-68.
Works in progress
Cortical mechanisms of stimulus processing and attention
Involvement of glio-transmitters in cognitive dysfunction
Cholinergic contributions to attentional dysfunction