Kyle S. Smith
Assistant Professor of Psychological and Brain Sciences
I conduct research on how the brain works to generate reward, motivation, actions, and habits. My work incorporates techniques to record neural activity, modulate neuronal activity at sub-second timescales, study brain chemistry, and map brain connections. The research is relevant to understanding disorders of reward and action, like addiction, Parkinson’s disease, and obsessive-compulsive spectrum disorders.
Graybiel AM, Smith KS (2014). How the brain makes and breaks habits. Scientific American, June issue (cover article). Link to site.
Smith KS, Graybiel AM (2014). Investigating habits: strategies, technologies, and models. Frontiers in Behavioral Neuroscience, 8:39. Link to article.
Smith KS, Graybiel AM (2013). A dual operator view of habitual behavior reflecting cortical and striatal dynamics. Neuron, 79(2):361-74. (Link for video abstract)
Smith KS, Graybiel AM (2013). Using optogenetics to study habits. Brain Research, 1511:102-14.
Smith KS, Virkud A, Deisseroth K, Graybiel AM (2012). Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex. Proceedings of the National Academy of Sciences, 109(46):18932-7.
Smith KS, Berridge KC, Aldridge JW (2011). Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. Proceedings of the National Academy of Sciences, 108(27):E255-64.
Smith KS, Tindell AJ, Aldridge JW, Berridge KC (2009). Ventral pallidum roles in reward and motivation. Behavioural Brain Research, 96(2):155-67.
Smith KS, Mahler SV, Peciña S, Berridge KC (2009). Hedonic hotspots: brain generation of sensory pleasures. In: Berridge KS and Kringelbach ML (Eds.), Pleasures of the Brain. Oxford, England: Oxford University Press.
Smith KS, Berridge KC (2007). Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. The Journal of Neuroscience, 27(7):1594-1605.
Smith KS, Berridge KC (2005). The ventral pallidum and hedonic reward: neurochemical maps of‘liking’and food intake. The Journal of Neuroscience, 25(38):8637-49.