Assistant Professor of Biological SciencesAdjunct Assistant Professor of Computer ScienceSimons Foundation Investigator in Mathematical Modeling of Living Systems
My research interests are to understand how microbes change over time. Recent advances in DNA sequencing technologies brought us an avalanche of data: thousands of genomes and terabases of environmental DNA (metagenomes). I mine these data sets to assess the impact of horizontal gene transfer on microbial populations, find new ways to characterize microbial communities, and track down genomic signatures of microbial adaptations.
Lori R. Shapiro, Erin D. Scully, Timothy J. Straub, Jihye Park, Andrew G. Stephenson, Gwyn Beattie, Mark Gleason, Roberto Kolter, Miguel C. Coelho, Consuelo M. DeMoraes, Mark C. Mescher, and Olga Zhaxybayeva: "Horizontal Gene Acquisitions, Mobile Element Proliferation, and Genome Decay in the Host-Restricted Plant Pathogen Erwinia tracheiphila", Genome Biol Evol. 2016, 8:649-664.
Pollo SM, Zhaxybayeva O, Nesbo CL: "Insights into thermoadaptation and the evolution of mesophily from the bacterial phylum Thermotogae." Can J Microbiol. 2015, 61:655-70.
Lossouarn J, Nesbo CL, Mercier C, Zhaxybayeva O, Johnson MS, Charchuck R, Farasin J, Bienvenu N, Baudoux AC, Michoud G, Jebbar M, Geslin C. "Menage a trois": a selfish genetic element uses a virus to propagate within Thermotogales. Environ Microbiol. 2015, 17:3278-88.
Nesbo CL, S Swithers K, Dahle H, Haverkamp TH, Birkeland NK, Sokolova T, Kublanov I, Zhaxybayeva O. (2014) "Evidence for extensive gene flow and Thermotoga subpopulations in subsurface and marine environments." ISME J. 2015, 9:1532-42.
Caroline E. Whidden, Katrina G. DeZeeuw, Jackie K. Zorz, Andrew P. Joy, David A. Barnett, Milo S. Johnson, Olga Zhaxybayeva, and Amanda M. Cockshutt (2014) “Quantitative and Functional Characterization of the Hyper-Conserved Protein of Prochlorococcus and marine Synechococcus”, PLoS ONE, 9: e109327.
Olga Zhaxybayeva, Ramunas Stepanauskas, Nikhil R. Mohan, and R. ThanePapke (2013) "Cell sorting analysis of geographically separated hypersaline environments", Extremophiles, 17: 265-75.
Olga Zhaxybayeva, et al. (2012) “Genome sequence of the mesophilic Thermotogales bacterium Mesotoga prima MesG1.Ag.4.2 reveals largest Thermotogales genome to-date”, Genome Biology and Evolution, 4: 700-708.
Andrew S. Lang, Olga Zhaxybayeva, and J. Thomas Beatty (2012) “Gene Transfer Agents: phage-like elements of genetic exchange”, Nature Reviews in Microbiology, 10: 472-482.
Earlier publications are available at http://www.dartmouth.edu/~ecglab/pubs.html