Publications - Books
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.
Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.
This book provides an introductory-level exploration of geophysical fluid dynamics (GFD), the principles governing air and water flows on large terrestrial scales. Physical principles are illustrated with the aid of the simplest existing models, and the computer methods are shown in juxtaposition with the equations to which they apply. It explores contemporary topics of climate dynamics and equatorial dynamics, including the Greenhouse Effect, global warming, and the El Nino Southern Oscillation.
Fourier Transforms: Principles and Applications explains transform methods and their applications to electrical systems from circuits, antennas, and signal processors—ably guiding readers from vector space concepts through the Discrete Fourier Transform (DFT), Fourier series, and Fourier transform to other related transform methods. Featuring chapter end summaries of key results, over two hundred examples and four hundred homework problems, and a Solutions Manual this book is perfect for graduate students in signal processing and communications as well as practicing engineers.
The control of vibrating systems is a significant issue in the design of aircraft, spacecraft, bridges, and high-rise buildings. This book discusses the control of vibrating systems, integrating structural dynamics, vibration analysis, modern control, and system identification. By integrating these subjects engineers will need only one book, rather than several texts or courses, to solve vibration control problems. The authors cover key developments in aerospace control and identification theory, including virtual passive control, observer and state-space identification, and data-based controller synthesis. They address many practical issues and applications, and show examples of how various methods are applied to real systems. Some methods show the close integration of system identification and control theory from the state-space perspective, rather than from the traditional input-output model perspective of adaptive control. This text will be useful for advanced undergraduate and beginning graduate students in aerospace, mechanical, and civil engineering, as well as for practicing engineers.
This book provides, for the first time, a broad and deep treatment of the fields of both ultra low power electronics and bioelectronics. It discusses fundamental principles and circuits for ultra low power electronic design and their applications in biomedical systems. It also discusses how ultra-energy-efficient cellular and neural systems in biology can inspire revolutionary low power architectures in mixed-signal and RF electronics. The book presents a unique, unifying view of ultra low power analog and digital electronics and emphasizes the use of the ultra-energy-efficient subthreshold regime of transistor operation in both. Chapters on batteries, energy harvesting, and the future of energy provide an understanding of fundamental relationships between energy use and energy generation at small scales and at large scales. A wealth of insights and examples from brain implants, cochlear implants, bio-molecular sensing, cardiac devices, and bio-inspired systems make the book useful and engaging for students and practicing engineers.
This is the first complete account of the physics of the creep and fracture of ice, and their interconnectivity. It investigates the deformation of low-pressure ice, which is fundamental to glaciers, polar ice sheets and the uppermost region of icy moons of the outer Solar System. The book discusses ice structure and its defects, and describes the relationship between structure and mechanical properties. It reviews observations and measurements, and then interprets them in terms of physical mechanisms. The book provides a road-map to future studies of ice mechanics, such as the behaviour of glaciers and ice sheets in relation to climate change and the dating of deep ice cores. It also highlights how this knowledge is transferable into an understanding of other crystalline materials. Written by experts in the field, it is ideal for graduate students, engineers and scientists in Earth and planetary science, and materials science.